A T-cell stimulatory protein and interleukin-10 synergize to prevent gut inflammation

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A T-cell stimulatory protein and interleukin-10 synergize to prevent gut inflammation

Researchers have found an unexpected synergy between a T-cell stimulatory protein—the ICOS ligand—and interleukin-10, an immunoregulatory cytokine, to prevent inflammatory bowel disease in mice. The study will aid the understanding of, and future research into, this immune disorder, which includes Crohn’s disease and ulcerative colitis. About 1.6 million Americans have inflammatory bowel disease.

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