In the largest study of its kind, researchers from Boston Children’s Hospital found neurological involvement in 22 percent of children and adolescents hospitalized with acute COVID-19 or multisystem inflammatory syndrome in children (MIS-C). These symptoms included fatigue, headache, confusion, difficulty walking or crawling, or loss of taste and smell. However, 1 in 8 children with neurological involvement developed life-threatening conditions including stroke, encephalitis, and Guillain-Barre syndrome.