COVID-19 may negatively affect sperm quality and reduce fertility in men, according to research published in Reproduction. The study indicates that COVID-19 infection can cause increased sperm cell death, inflammation, and oxidative stress, resulting in lower sperm quality and potentially reducing fertility. These findings provide the first, direct experimental evidence that the male reproductive system could be targeted and damaged by COVID-19, and suggest that men’s reproductive function should be evaluated after infection to detect and avoid further fertility problems.