Aging and lifestyle-related metabolic imbalances, such as hyperglycemia, hyperlipidemia, and oxidative-stress, cause the accumulation of advanced glycation end products (AGEs), including pentosidine (PEN, crosslinked type) and carboxymethyl-lysine (CML, non-crosslinked type). Osteoporosis is a widespread metabolic skeletal disease characterized by diminished bone mineral density (BMD) or bone strength, which increases the risk of fractures.