Diabetes: TXNIP involved in increased secretion of glucagon from pancreatic alpha cells
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27 September 2022Diabetes: TXNIP involved in increased secretion of glucagon from pancreatic alpha cells
In diabetes research over the past two decades, Anath Shalev, M.D., has shown that the protein TXNIP regulates survival and function of beta cells, the pancreatic cells that produce the hormone insulin to lower levels of glucose in the blood. Downregulation or inhibition of TXNIP in beta cells protects against diabetes in mouse models, and a repurposed clinical drug that inhibits TXNIP shows promising results in people with recent-onset type 1 diabetes.
