Huntington’s disease (HD) is a hereditary brain disease caused by a mutation in the huntingtin gene. HD is a neurodegenerative disease without a cure that, after the onset of the disease at around 40 years of age, causes changes in personality and symptoms of dementia along with uncontrollable convulsive movements, ultimately leading to death. It is known that such HD symptoms are caused by the destruction of brain cells in the striatum due to problems occurring in synapses that are crucial to brain function during the progression of the disease. However, the specific mechanism behind brain dysfunction during the progression of HD has not been fully elucidated.