A new study confirms that for men who are at heightened genetic risk of developing prostate cancer, genes are not destiny. Investigators from Brigham and Women’s Hospital looked at outcomes for men with nearly 30 years of follow-up for prostate cancer risk and prostate cancer mortality who were enrolled in two cohort studies—the Health Professionals Follow-up Study and the Physicians’ Health Study. The team found that while men who followed a healthy or unhealthy lifestyle were equally likely to be diagnosed with prostate cancer, adherence to a healthy lifestyle was associated with close to a 50 percent reduced risk of developing lethal prostate cancer. Results are published in European Urology.