In Down syndrome cells, genome-wide disruptions mimic a senescence-like state
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6 January 2022In Down syndrome cells, genome-wide disruptions mimic a senescence-like state
In Down syndrome, the third copy of chromosome 21 causes a reorganization of the 3D configuration of the entire genome in a key cell type of the developing brain, a new study shows. The resulting disruption of gene transcription and cell function are so similar to those seen in cellular aging, or senescence, that the scientists leading the study found they could use anti-senescence drugs to correct them in cell cultures.
