New technique solves HIV capsid structure and could be blueprint of capsid-targeting antivirals
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19 November 2021New technique solves HIV capsid structure and could be blueprint of capsid-targeting antivirals
A new technique using electron tomography and subtomogram averaging at Diamond’s electron Bio-Imaging Centre (eBIC), has solved the structure of the HIV capsid alone and in complex with host factors. This work also led to the building of an atomistic model of the whole HIV capsid using information gained from electron tomography, which the team believes could serve as a blueprint for the development of capsid-targeting antivirals.
