Acute lymphoblastic leukemia (ALL), a cancer involving white blood cells known as lymphocytes, is the most common childhood cancer, representing 25% of all cancer diagnoses. It’s also one of the leading causes of childhood cancer deaths. While cure rates have improved thanks to chemotherapy, the cancer treatments are toxic. Survivors face increased risk of heart disease, lung disease, neurocognitive defects as well as increased risk of developing a secondary cancer in their lifetime.