Researchers are one step closer to understanding the physiology of antidepressant action in the brain. They have confirmed that even when brain cells are not active, they trigger protein production that affects the function of cells and neural circuits. The work was conducted in the labs of Ege Kavalali, professor and acting chair of the Department of Pharmacology and William Stokes Chair in Experimental Therapeutics, and Lisa Monteggia, professor of pharmacology.