Hepatitis B virus (HBV) remains endemic throughout sub-Saharan Africa despite the widespread availability of effective childhood vaccines. In the Democratic Republic of the Congo, HBV treatment and birth-dose vaccination programs are not established. UNC School of Medicine researchers led a study to evaluate the feasibility and acceptability of HBV testing and treatment of pregnant women, as well as birth-dose vaccination of HBV-exposed infants. This program was added to existing public health infrastructure to prevent mother-to-child transmission of HBV in the Democratic Republic of the Congo.