Skeletal muscle is the largest organ in the body. It accounts for 30 to 40% of body weight and is responsible for multiple functions such as energy metabolism and heat production. However, skeletal muscle mass is reduced in some diabetics, and that muscle loss correlates with mortality. It has been reported that the differentiation of myoblasts, which are the muscle precursor cells, is reduced in diabetic patients, and this is thought to be one of the underlying causes of muscle loss.