Hepatitis C virus (HCV) may cause chronic infection to the liver, which can result in irreversible liver damage and liver cancer. How HCV manages to evade the immune system to infect the host chronically is not entirely understood. In a new study, researchers from Osaka University discovered a novel molecular mechanism by which HCV interferes with the host’s immune system to cause chronic liver infection. These findings may help establish a novel therapy against chronic HCV infection.