The endocrine system is strongly involved in SARS-Cov-2 infection—so much so that evidence of an ‘endocrine phenotype’ of COVID-19 has emerged, according to a statement by the European Society of Endocrinology (ESE) published in the journal Endocrine in April 2021. Leading endocrinology researchers looked into the evidence that has accumulated over the past year since the pandemic emerged, and consistently found evidence for links across a variety of endocrine conditions. This statement constitutes an update of a March 2020 statement that was of the earliest and most read pieces delineating the involvement of the endocrine system in COVID-19.