Researchers reveal mechanism for α-syn deposition in familial Parkinson’s disease
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13 May 2021Researchers reveal mechanism for α-syn deposition in familial Parkinson’s disease
Amyloid deposition of α-synuclein (α-syn) is a hallmark of Parkinson’s disease (PD). α-Syn fibrillation and cell-to-cell transmission in the brain play an essential role in disease progression. To date, eight single-point mutations of SNCA have been identified in familial PD (fPD), which feature early-onset, severe and highly heterogeneous clinical symptoms.
