Aluminum is intricately associated with the neuropathology of familial Alzheimer’s disease
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9 April 2021Aluminum is intricately associated with the neuropathology of familial Alzheimer’s disease
A new study builds upon two earlier published studies (Mold et al., 2020, Journal of Alzheimer’s Disease Reports) from the same group. The new data, also published in the Journal of Alzheimer’s Disease Reports, demonstrate that aluminum is co-located with phosphorylated tau protein, present as tangles within neurons in the brains of early-onset or familial Alzheimer’s disease (AD). “The presence of these tangles is associated with neuronal cell death, and observations of aluminum in these tangles may highlight a role for aluminum in their formation,” explained lead investigator Matthew John Mold, Ph.D., Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, UK.
