Artificial intelligence can augment current methods to predict the risk that head and neck cancer will spread outside the borders of neck lymph nodes, according to researchers with the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN). A customized deep learning algorithm using standard computed tomography (CT) scan images and associated data contributed by patients who participated in the E3311 phase 2 trial shows promise, especially for patients with a new diagnosis of human papillomavirus (HPV)-related head and neck cancer. The E3311 validated dataset carries the potential to contribute to the more accurate staging of disease and prediction of risk.