Cirrhosis of the liver is associated with decreased responsiveness to COVID-19 mRNA vaccines as evidenced by results after two doses. However, the results of a new study strongly support giving the recommended booster vaccinations to these patients. In this retrospective study of over 26,000 patients with cirrhosis, investigators found there was an 80% reduction in COVID-19 occurrence, 100% reduction in severe or critical COVID-19, and 100% reduction in COVID-19-related death. Their findings are reported in the Journal of Hepatology.