The process of metastasis is when cancer cells gain motility and spread to other sites of the body. Because this is one of the main causes of cancer-related deaths, researchers have aimed to develop therapeutic strategies that can block metastasis. In a recent article published in Cell Reports, a team led by researchers at Tokyo Medical and Dental University (TMDU) describe how a cell signaling molecule called transforming growth factor-β (TGF-β) can help oral cancer cells acquire such dangerous motility.