In a new Annals of Internal Medicine “Beyond the Guidelines” feature, a primary care physician and a gastroenterologist discuss the recommendation to begin colorectal cancer (CRC) screening at age 45, review options for CRC screening, and discuss how to choose among the available options. All “Beyond the Guidelines” features are based on the Department of Medicine Grand Rounds at Beth Israel Deaconess Medical Center (BIDMC) in Boston and include print, video, and educational components published in Annals of Internal Medicine.