A multidisciplinary, international team formed around Drs Lorenz Thurner and Jochen Pfeifer (both University Hospital Homburg/Saar, Germany) as well as Dr. Christoph Kessel (University Children’s Hospital, Münster, Germany) and Prof. Karin Klingel (University Hospital Tübingen, Germany) provides new observations in the context of myocarditis after SARS-CoV-2 vaccination, pinpointing a potential role of autoantibodies towards IL-1Ra in the pathophysiology.