Researchers from the Organoid group (formerly the Clevers group) have improved human small intestinal organoids—miniature versions of the small intestine. This will help them to better study the functioning of the small intestine during health and disease. Specifically, the researchers managed to develop organoids that contain mature Paneth cells, which were not present in the previous human small intestinal organoids. The results of the study were published on 23 August in Cell Stem Cell.