It has become obvious that sufficiently high immunity to COVID-19 cannot be achieved in Germany through voluntary vaccination alone. On this background, Thomas Rieger and Carsten Schröder from the German Institute for Economic Research, Berlin, together with Christoph Schmidt-Petri from the Karlsruhe Institute of Technology, investigated the acceptance of a policy of general mandatory vaccination against COVID-19. The scientists also investigated the questions of which population groups are supportive of such a measure, which ones are opposed, and what their reasons are, respectively.