Changes in DNA can lead to the development and progression of cancer. DNA serves as a template for an intermediary molecule called RNA that, in turn, codes for proteins that control all cellular processes. Most cancer research and available anticancer drugs focus on the impact of DNA and protein alterations that contribute to cancer; however, it is now understood that RNA molecules can also both positively and negatively impact the development of cancer. In a new article published in Cancer Research, a journal of the American Association for Cancer Research, Moffitt Cancer Center researchers describe how RNA molecules promote the development of melanoma metastasis by impacting anti-tumor microRNA.