The American College of Medical Genetics and Genomics (ACMG) has released an update to the recommended minimum gene list for the reporting of secondary findings (SF). In 2021, the ACMG Board of Directors and Secondary Findings Working Group (SFWG) declared that the College would update the list (SF v3.0) annually. Today’s update (SF v3.1) adds five new genes—four associated with dilated cardiomyopathy predisposition and one associated with hereditary transthyretin amyloidosis, a cause of heart failure.