The Geneva Centre for Emerging Viral Diseases shares the first sequencing results of the monkeypox genome from Switzerland. This important step will enable further analysis and comparison with genome sequences from other countries. According to preliminary results, the virus sequence of the first two cases in Switzerland is genomically linked to cases reported in several other countries in the context of the current outbreak. The National Reference Laboratory for Emerging Viruses (CRIVE) team shares its genome with the scientific community, via the Platform Genbank.