Study finds Stat5-/- CD4+ T cells elicit an anti-melanoma effect by CD4+ T cell remolding and Notch1 activation
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12 May 2022Researchers seek to improve success of chimeric antigen receptor-T cell therapy in non-Hodgkin lymphoma
12 May 2022Study finds Stat5-/- CD4+ T cells elicit an anti-melanoma effect by CD4+ T cell remolding and Notch1 activation
Tumor-infiltrating lymphocytes (TILs) play a key role in the antitumor immune response and various types of immunotherapies. Recently, studies have shown that CD4+ T cells and CD8+ T cells are equally important for an efficient antitumor immune response, and in specific tumor settings, CD4+ T cell-mediated tumor killing effects can even outcompete that of CD8+ T cells.
