Drug-induced parkinsonism is not well understood. Chronic use of flunarizine (FNZ), a drug often used for treating dizziness, migraine, epilepsy, and peripheral vascular diseases, may induce parkinsonism. Previous investigations point out that the disruption of mitochondrial quality control, essential for mitochondrial homeostasis and function, degrades brain functions, and is causally related to parkinsonism disease. Still, there is limited knowledge about the exact mechanism of drug-induced parkinsonism, which hinders the development of prevention and treatment.