A new study published this week in mBio, an open access journal of the American Society for Microbiology, has opened the door to a new approach to attacking herpesviruses. The study demonstrated that targeting 2 metal ion-dependent enzymes of human herpesviruses with 2 compounds, AK-157 and AK-166, can inhibit the replication of the virus. The finding provides new opportunities to developing agents against herpesviruses.