Tissue engineered vascular grafts (TEVGs) can advance surgical management of infants and children who require congenital heart surgery, by creating functional vascular conduits with growth capacity. In a new report now published in Communication Medicine, Kevin G. Blum, Jacob C. Zbinden, Abhay B. Ramachandra and a large team of multidisciplinary and multi-institutional researchers used an integrative computational-experimental approach to understand the natural history of neovessel formation in a large preclinical animal model. During the experiments they combined large animal implantation studies with in vivo imaging and histology alongside computational growth and remodeling methods. The outcomes can provide insights to TEVG (tissue-engineered vascular graft) remodeling, with important implications for clinical translation for children with congenital heart disease.