Virtually guided prolonged exposure therapy reduced post-traumatic stress disorder (PTSD) symptoms more effectively than prolonged exposure alone in a pilot study of 40 civilians and veterans. The study was conducted at the Medical University of South Carolina (MUSC) and in partnership with the Ralph H. Johnson VA Medical Center. Given that up to 8% of the U.S. population and 20% of veterans are affected by PTSD, this study’s findings are important in expanding the reach of therapy for PTSD.