Scientists at St. Jude Children’s Research Hospital have a new understanding of how a group of well-known fusion oncoproteins causes leukemia. The findings show the importance of liquid-liquid phase separation (LLPS), a process cells use to organize proteins and other molecules. LLPS is a key part of the mechanism driven by NUP98 fusion oncoproteins that transforms blood stem cells into leukemia. A paper on the work was published today in Cancer Discovery, a journal of the American Association for Cancer Research.