Researchers reveal inner nuclear membrane protein as positive regulator in breast cancer metastasis
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8 December 2021Researchers reveal inner nuclear membrane protein as positive regulator in breast cancer metastasis
The nuclear envelope (NE) is composed of the outer nuclear membrane (ONM) and the inner nuclear membrane (INM), which are separated by the perinuclear space and joined at nuclear pore complexes. INM proteins play crucial roles in cell cycle regulation, DNA repair, aging, and cell migration of tumor formation and progression. However, the specific INM proteins and INM protein-based mechanisms contributing to cancer aggressiveness remain to be investigated.
