Researchers have recently discovered that certain enzymes binded to each other may help lessen the risk of developing mesothelioma, a cancer of the lining of the lungs and abdomen. The study from University of Hawaiʻi Cancer Center’s Flavia Novelli, Michele Carbone and Haining Yang was published in the Proceedings of the National Academy of Sciences of the U.S. They reported that the interaction of BAP1 (a tumor suppressor gene), HMGB1 (nuclear protein) and HDAC1 (hemoglobin) form a trimer, a macromolecular component made up of multiple molecules, which may improve mesothelioma outcomes.