The last drug designed to more effectively treat dangerous systemic fungal infections, most often affecting immunocompromised patients, was developed over 20 years ago. Now an interdisciplinary team of investigators from Stony Brook University believe they have identified what may be a new approach toward developing another class of better antifungal agents. By inhibiting an enzyme called sterylglucosidase 1 (Sgl1) in a model of Cryptococcosis, the researchers found infection did not spread. They believe this enzyme can be a target for a new class of antifungal drugs. The research findings are published in Nature Communications.