Accumulated DNA damage linked to neurodegeneration in a rare pediatric disorder
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15 October 2021Accumulated DNA damage linked to neurodegeneration in a rare pediatric disorder
Unrepaired DNA damage is primarily responsible for the devastating neurodevelopmental abnormalities associated with Aicardi-Goutières syndrome (AGS), a rare childhood disorder. The findings from St. Jude Children’s Research Hospital overturn the belief that neuroinflammation was to blame. The paper appeared today in Neuron.
