Inhibition of the Aurora Kinase A protein may help overcome lung cancer resistance to KRAS inhibition
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7 October 2021Inhibition of the Aurora Kinase A protein may help overcome lung cancer resistance to KRAS inhibition
In preclinical models, combining an investigational Aurora Kinase A (AURKA) inhibitor with a KRAS inhibitor or a WEE1 inhibitor showed efficacy against lung cancer cells with intrinsic or acquired resistance to KRAS inhibition, according to results presented at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics, held October 7-10, 2021.
