Researchers identify a mechanism that can help guide the development of new STING-activating drugs using imaging

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Researchers identify a mechanism that can help guide the development of new STING-activating drugs using imaging

A new study from scientists at the UCLA Jonsson Comprehensive Cancer Center found that emerging drugs that activate the protein STING, a well-established regulator of immune cell activation, substantially alter the activity of metabolic pathways responsible for generating the nucleotide building blocks for DNA. Researchers found that these alterations occur in cancer cells and can be visualized using [18F]FLT positron emission tomography (PET) imaging, marking the first time the effects of these drugs have been traced using a noninvasive imaging technique.

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