According to a study by The Wistar Institute, the tumor suppressor Parkin, whose levels are reduced in different cancer types, causes acute metabolic and oxidative stress, suppresses mitochondrial trafficking, and blocks tumor cell movement, reducing primary and metastatic tumor growth. These findings, published today in Science Advances, demonstrate that metabolic and mitochondrial reprogramming, which are well-established hallmarks of tumor progression, act as potent drivers of disease.