Inhibition of key pathway promotes iron-dependent cell death in pancreatic cancer cells
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11 August 2021Inhibition of key pathway promotes iron-dependent cell death in pancreatic cancer cells
One of the reasons pancreatic cancer remains the most deadly of the major cancers is that it craftily rewires normal cell survival mechanisms to keep itself supplied with nutrients to fuel its expansion.A new study led by the University of Michigan Rogel Cancer Center demonstrates how inhibiting a key enzyme known as GOT1 can flip a switch in the cancer cells—causing them to shift from using nutrients to fuel growth toward conserving them to maintain energy levels.
