The loss of muscle tissue—referred to as muscle atrophy in medical terms—can occur as a result of lack of physical activity for an extended period of time; aging; alcohol-associated myopathy—a pain and weakness in muscles due to excessive drinking over long periods of time; burns; injuries; malnutrition; spinal cord or peripheral nerve injuries; stroke; and long-term corticosteroid therapy. While muscle atrophy due to disuse is well-known and studied, the underlying cellular mechanisms, particularly the status of mitochondrial degradation by mitophagy during disuse-induced muscle atrophy, has been a subject of debate among cellular physiologists, as mitochondria are abundant in skeletal muscles.