When the World Health Organization declared the COVID-19 outbreak a pandemic, the health crisis catalyzed a global effort to accelerate innovation and stop the novel virus’s spread. To help streamline that effort, the MIT Center for Collective Intelligence, MIT Media Lab’s Community Biotechnology Initiative, and MilliporeSigma, the life science business of Merck KGaA, Darmstadt, Germany, together convened more than 180 thought leaders from around the globe to collaborate asynchronously and rapidly identify solutions. A comprehensive report that synthesizes data-driven insights from this expert group, known as the “Pandemic Response Supermind,” has now been published, outlining the most promising solutions for pandemic response.