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Study of NCOA3 yields novel findings of melanoma progression

For the first time, activation of nuclear receptor coactivator 3 (NCOA3) has been shown to promote the development of melanoma through regulation of ultraviolet radiation (UVR) sensitivity, cell cycle progression and circumvention of the DNA damage response. Results of a pre-clinical study led by Mohammed Kashani-Sabet, M.D., Medical Director of the Cancer Center at Sutter’s California Pacific Medical Center (CPMC) in San Francisco, CA were published online today in Cancer Research, a journal of the American Association for Cancer Research.

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