The fast-spreading UK, South Africa, and Brazil coronavirus variants are raising both concerns and questions about whether COVID-19 vaccines will protect against them. New work led by Bing Chen, Ph.D., at Boston Children’s Hospital analyzed how the structure of the coronavirus spike proteins changes with the D614G mutation—carried by all three variants—and showed why these variants are able to spread more quickly. The team reports its findings in Science (March 16, 2021).