The impact of the COVID-19 pandemic on public health is staggering; more than one hundred million cases and two million deaths worldwide. In response, most countries and local governments have taken substantial measures—such as travel restrictions and physical distancing—to keep their citizens safe. Both the pandemic and related protective measures pose challenges for ongoing clinical research studies seeking to treat and prevent the world’s greatest public health emergencies including COVID-19, but also Alzheimer’s disease and other dementia.