NUS pharmaceutical scientists have developed a systematic approach to understand how the human body manages two new psychoactive substances (NPS) by predicting their biological half-lives and measuring their biological activities against cannabinoid receptors. These NPS are synthetic cannabinoids (SCs) abbreviated as 5F-MDMB-PINACA and 4F-MDMB-BINACA. Their findings will help develop guidelines to detect the ingestion of SCs among abusers and better manage their toxicity manifestations.