The sight of healthcare workers wearing personal protective equipment (PPE) to protect against transmission of SARS-CoV-2 is something the world has become accustomed to. However, a new study analysing the impact of PPE staff shows that the number and variety of issues they experience increases as their time in PPE without a break increases, ranging from tiredness and headaches in the first hour to nausea, vomiting and dizziness as they head towards four hours continuously in PPE.