COVID-19 infections are once again rising at an alarming rate in San Francisco’s Latinx community, predominantly among low-income essential workers, according to results of a massive community-based testing blitz conducted before and after the Thanksgiving holiday by Unidos En Salud—a volunteer-led partnership between the Latino Task Force for COVID-19 (LTF), UC San Francisco, the Chan Zuckerberg Biohub (CZ Biohub), and the San Francisco Department of Public Health (SFDPH).