The impact of the COVID-19 pandemic on children with disabilities has not received much attention, perhaps because the disease disproportionately affects older individuals. In this special issue of the Journal of Pediatric Rehabilitation Medicine experts assess the impact of the pandemic on pediatric patients with special needs, their caregivers, and healthcare providers. They also focus on the growing importance of telemedicine and provide insights and recommendations for mitigating the impact of the virus in the short and long term.